IMMUNOLOGY

This overview highlights emerging treatments for neovascular AMD, including new tyrosine kinase inhibitors and promising gene therapy programs. Clinical trials over the next two years may bring long-term, more durable treatment options for patients.

The WILLOW trial reveals Enpatoran’s strong performance in mucocutaneous lupus, achieving high CLASI-50 and CLASI-70 response rates, remission milestones, and rapid IFN gene suppression in both CLE and SLE patients.

The phase 3 VALOR trial shows that brepocitinib significantly improves skin disease, muscle strength, and functional disability in adults with dermatomyositis. As the first modern targeted therapy to demonstrate positive results, brepocitinib may transform treatment options while reducing steroid reliance.