A retrospective cohort study from UCLA reveals that the sustained use of medications for alcohol use disorder (MAUD) for three months or longer is associated with significantly improved 1-year and 3-year survival rates among patients with severe alcohol-related liver disease undergoing transplant evaluation.
The MetALD-ALD Prediction Index (MAPI) is a validated diagnostic tool that utilizes five routine biomarkers (sex, MCV, GGT, HDL, HbA1c) to distinguish metabolic from alcohol-associated steatotic liver disease, bypassing the unreliability of patient self-reporting. Achieving ~76% diagnostic accuracy across international cohorts, MAPI establishes cost-effective triage cutoffs: a score $\le$ 0.09 effectively rules out significant alcohol involvement (94% NPV), while a score $\ge$ 0.33 identifies high-risk patients requiring confirmatory PEth testing.
๐ง + ๐ฆ = ๐ฅ Mental health matters in IBD.
Psychiatric disorders are *common* among patients with inflammatory bowel diseaseโup to **57%** affected.
The gut and brain are deeply connected.
#IBD #MentalHealth #GutBrainAxis @sunilmadhavs.world
Long-term adherence to Mediterranean and plant-based diets cuts chronic constipation risk by up to 20%, while Western and inflammatory diets raise it over 20%. Benefits go beyond fiber, likely involving gut microbiome effects, highlighting dietโs preventive role.
