The MetALD-ALD Prediction Index (MAPI) is a validated diagnostic tool that utilizes five routine biomarkers (sex, MCV, GGT, HDL, HbA1c) to distinguish metabolic from alcohol-associated steatotic liver disease, bypassing the unreliability of patient self-reporting. Achieving ~76% diagnostic accuracy across international cohorts, MAPI establishes cost-effective triage cutoffs: a score $\le$ 0.09 effectively rules out significant alcohol involvement (94% NPV), while a score $\ge$ 0.33 identifies high-risk patients requiring confirmatory PEth testing.

Discontinuing SSRIs or SNRIs during pregnancy was associated with nearly double the risk of mental health emergencies, according to a cross-sectional analysis of 3,983 women. While prepregnancy psychiatric visit rates were similar between groups, antidepressant discontinuation was linked to significantly higher emergency department visits for psychiatric indications, particularly during the first and ninth months of pregnancy. These findings highlight the maternal risks of routine antidepressant discontinuation and reinforce the importance of individualized risk–benefit counseling during pregnancy.

A large UK Biobank analysis found that higher serum vitamin D levels were associated with a lower risk of hospitalization for respiratory tract infections, while severe deficiency increased risk. Although causality remains unproven, the findings position vitamin D status as a potentially modifiable factor in preventive health strategies.

Statin Therapy and Risk of Acute Exacerbations in Adults With Mild Asthma Background     Statins, widely prescribed for cardiovascular disease prevention, exhibit pleiotropic effects that extend beyond lipid lowering. …

FDA Restrictions on Non-Approved GLP-1 API Use and Marketing   The US Food and Drug Administration (FDA) has announced plans to implement restrictions on the use of glucagon-like peptide-1 (GLP-1) …

Association Between Target Urate Levels and Cardiovascular Outcomes in Gout   Data published in JAMA Internal Medicine indicates that patients with gout who successfully achieve a serum urate level of …

Analysis of Statin Safety and Adverse Event Attribution A large-scale analysis published in *The Lancet* offers significant reassurance regarding the tolerability of statin therapy, finding that the vast majority of …

Benefits and Risks of PFO Closure by Causal Likelihood A recent meta-analysis suggests that the benefits of transcatheter PFO closure for secondary stroke prevention rely heavily on the likelihood that …

  A novel cellular rejuvenation therapy, ER-100, has received clearance from the U.S. Food and Drug Administration (FDA) to proceed with human clinical testing, marking what the sponsor describes as …